Closing in on the Target: Sustained Virologic Response in Hepatitis C Virus Genotype 1 Infection Response-Guided Therapy

Closing in on the target: sustained virologic response in hepatitis C virus genotype 1 infection response-guided therapy.

Retrospective analyses of the boceprevir and telaprevir phase 3 trial data demonstrate the clinical relevance of detected but not quantifiable hepatitis C virus (HCV) genotype 1 RNA during treatment. These analyses illustrate the importance of using precise and standard terminology in reporting low-level HCV RNA results for consistent data collection across clinical trials, and to ensure optima...

the correlation of il28b genotype with sustained virologic response in romanian patients with chronic hepatitis c

Hepatitis C Virus Late Relapse after Sustained Virologic Response

24 Hepatitis C (HCV) viremia is unusual (<5%) after successful treatment, defined as sustained 25 virologic response (SVR) or undetectable HCV PCR 12-24 weeks after therapy. We present a 26 case of late virologic relapse (de novo infection excluded by RNA sequencing) after SVR 27 followed by spontaneous viral clearance. 28

Response-guided therapy for patients with hepatitis C virus genotype 6 infection: a pilot study.

The optimal duration of treatment with pegylated interferon (PEG-IFN) plus ribavirin (RBV) in patients with hepatitis C virus (HCV) genotype 6 is unknown. This study was aimed at determining treatment response on the basis of rapid virological response (RVR) of HCV genotype 6 in comparison with genotypes 1 and 3. Sixty-six treatment naïve patients were treated with PEG-IFN-α2a (180 μg/week) plu...

The Correlation of Il28B Genotype With Sustained Virologic Response In Romanian patients With Chronic Hepatitis C

BACKGROUND Multiple variables influencing the sustained virologic response (SVR) in chronic hepatitis C have been evaluated. One of them is genetic polymorphism near the IL28B gene. OBJECTIVES The aim of this study was to evaluate the influence of IL28B genotypes on SVR rates in a group of patients with chronic hepatitis C from the western part of Romania. PATIENTS AND METHODS A retrospecti...